Cardiovascular benefits of Momordica charantia in cholesterol-fed Wistar rats

Abstract Background Momordica. charantia is popularly used as a medicinal herb in ethnomedicine for the management of cardiovascular diseases. In this study, we evaluated beneficial effects ethanolic extract M. (Linn.) experimentally induced disorders using cholesterol-fed Wistar rat. Methods Seventy-two experimental rats were randomly assigned into nine 9 groups 8 each and treated follows: Rats group A (control) given distilled water only; B 30 mg/kg cholesterol dissolved coco-nut oil (cholesterol solution); C solution 100 Atorvastatin; D 250 solution; E 500 F mg/kg. ; G H 1 ml coconut oil; I Atorvastatin. Results Mean LDL-cholesterol was significantly ( P < 0.05) lower F, compared with control groups. Histological analysis heart aortic branch show that administration myocardial degeneration, vascular ulceration stenosis aorta heavy perivascular infiltrates inflammatory cells. However, these deleterious ameliorated upon treatment Momordica Atorvastatin Conclusion Our findings indicate possible benefits .